A personalized approach to acute myeloid leukemia therapy: current options

Illangeswaran, RSS ; Das, S ; Paul, DZ ; Mathews, V ; Balasubramanian, P (2019) A personalized approach to acute myeloid leukemia therapy: current options Pharmacogenomics and Personalized Medicine (12). pp. 167-179. ISSN 1178-7066

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Official URL: http://doi.org/10.2147/PGPM.S168267

Related URL: http://dx.doi.org/10.2147/PGPM.S168267

Abstract

Therapeutic options for acute myeloid leukemia (AML) have remained unchanged for nearly the past 5 decades, with cytarabine and anthracyclines and use of hypomethylating agents for less intensive therapy. Implementation of large-scale genomic studies in the past decade has unraveled the genetic landscape and molecular etiology of AML. The approval of several novel drugs for targeted therapy, including midostaurin, enasidenib, ivosidenib, gemtuzumab-ozogamicin, and CPX351 by the US Food and Drug Administration has widened the treatment options for clinicians treating AML. This review focuses on some of these novel therapies and other promising agents under development, along with key clinical trial findings in AML.

Item Type:Article
Source:Copyright of this article belongs to Dove Press Ltd.
ID Code:124139
Deposited On:04 Nov 2021 07:30
Last Modified:04 Nov 2021 07:36

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