TARGET: a survey of real‐world management of chronic myeloid leukaemia across 33 countries

Turkina, Anna ; Wang, Jianxiang ; Mathews, Vikram ; Saydam, Guray ; Jung, Chul Won ; Al Hashmi, Hani Hassan ; Yassin, Mohamed ; Le Clanche, Solenn ; Miljkovic, Darko ; Slader, Cassandra ; Hughes, Timothy P. (2020) TARGET: a survey of real‐world management of chronic myeloid leukaemia across 33 countries British Journal of Haematology, 190 (6). pp. 869-876. ISSN 0007-1048

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Official URL: http://doi.org/10.1111/bjh.16599

Related URL: http://dx.doi.org/10.1111/bjh.16599

Abstract

Despite the availability of guidelines for the management of chronic myeloid leukaemia (CML), various issues may prevent their successful implementation. The TARGET survey examined real-world management of CML patients compared with international recommendations. This online survey was completed in 2017. Results were discussed by a Steering Committee (SC) of eight international haematologists, challenges were identified and practical solutions developed. Of the 1008 haematologists invited (33 countries), 614 completed the survey. Gaps regarding treatment efficacy and molecular monitoring were identified. Half of the physicians did not perform three-monthly testing of during the initial 12 months of treatment, citing cost as the major barrier, although they know it should be done. Treatment-free remission was not considered a primary treatment goal or as a priority factor influencing treatment decisions. European Leukemia Net guidelines interpretation was generally acceptable, but awareness regarding management of persistent adverse events was poor. Practical solutions proposed by the SC were mostly focused on enhancing physician education and awareness, or encouraging hospitals to work with the government, in order to improve the quality of BCR-ABL testing. Gaps in current CML management were identified compared with international recommendations, which the proposed practical solutions would help to address.

Item Type:Article
Source:Copyright of this article belongs to British Society for Haematology.
ID Code:124095
Deposited On:03 Nov 2021 10:59
Last Modified:03 Nov 2021 10:59

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