Roy, Biswajit ; Kundu, Moumita ; Singh, Amit Kumar ; Singha, Tara ; Bhattacharya, Sayantan ; Datta, Prasanta Kumar ; Mandal, Mahitosh ; Singh, N. D. Pradeep (2019) Stepwise dual stimuli triggered dual drug release by a single naphthalene based two-photon chromophore to reverse MDR for alkylating agents with dual surveillance in uncaging steps Chemical Communications, 55 (87). pp. 13140-13143. ISSN 1359-7345
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Official URL: http://doi.org/10.1039/C9CC05604A
Related URL: http://dx.doi.org/10.1039/C9CC05604A
Abstract
In this work, we depleted glutathione (GSH) by releasing SO2 with internal stimulus GSH itself, and also selectively marked the cancer cells followed by release of anticancer drug using another orthogonal stimulus i.e., two-photon (TP) NIR light by a single naphthalene based chromophore (TP absorbance 77 GM and uncaging cross-section 21 GM). We demonstrated the improved therapeutic efficacy of chlorambucil by the stepwise dual stimuli approach and dual surveillance of both the drug uncaging process in real-time using in vitro studies.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Chemistry. |
| ID Code: | 124071 |
| Deposited On: | 02 Nov 2021 07:11 |
| Last Modified: | 02 Nov 2021 07:11 |
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