A two-photon responsive naphthyl tagged p-hydroxyphenacyl based drug delivery system: uncaging of anti-cancer drug in the phototherapeutic window with real-time monitoring

Singh, Amit Kumar ; Kundu, Moumita ; Roy, Samrat ; Roy, Biswajit ; Shah, Sk. Sheriff ; Nair, Asha V ; Pal, Bipul ; Mondal, Mahitosh ; Singh, N. D. Pradeep (2020) A two-photon responsive naphthyl tagged p-hydroxyphenacyl based drug delivery system: uncaging of anti-cancer drug in the phototherapeutic window with real-time monitoring Chemical Communications, 56 (69). pp. 9986-9989. ISSN 1359-7345

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Official URL: http://doi.org/10.1039/D0CC01903H

Related URL: http://dx.doi.org/10.1039/D0CC01903H

Abstract

We report a two-photon responsive drug delivery system (DDS), namely, p-hydroxyphenacyl–naphthalene–chlorambucil (pHP–Naph–Cbl), having a two-photon absorption (TPA) cross-section of ≥20 GM in the phototherapeutic window (700 nm). Our DDS exhibited both AIE and ESIPT phenomena, which were utilized for the real-time monitoring of anti-cancer drug release.

Item Type:Article
Source:Copyright of this article belongs to Royal Society of Chemistry.
ID Code:124049
Deposited On:02 Nov 2021 05:38
Last Modified:02 Nov 2021 05:38

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