Strategic use of retro Diels-Alder reaction in the construction of β -carboxy-α-methylene-γ-lactones. Total synthesis of methylenolactocin and protolichesterinic acid

Ghatak, Anjan ; Sarkar, Subrata ; Ghosh, Subrata (1997) Strategic use of retro Diels-Alder reaction in the construction of β -carboxy-α-methylene-γ-lactones. Total synthesis of methylenolactocin and protolichesterinic acid Tetrahedron, 53 (51). pp. 17335-17342. ISSN 0040-4020

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/S0040-4020(97)10157-0

Abstract

A facile route for the construction of β -carboxy-α-methylene-γ -lactone unit is described using retro Diels-Alder reaction as the key step. Using this protocol, total synthesis of (± )-methylenolactocin and (± )-protolichesterinic acid has been achieved.

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ID Code:12343
Deposited On:10 Nov 2010 05:43
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