Singh, Akhilesh K. ; Yadav, Viveka Nand ; Pyaram, Kalyani ; Mullick, Jayati ; Sahu, Arvind (2009) Mapping of Functional Domains in Herpesvirus Saimiri Complement Control Protein Homolog: Complement Control Protein Domain 2 Is the Smallest Structural Unit Displaying Cofactor and Decay-Accelerating Activities Journal of Virology, 83 (19). pp. 10299-10304. ISSN 0022-538X
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Official URL: http://doi.org/10.1128/JVI.00217-09
Related URL: http://dx.doi.org/10.1128/JVI.00217-09
Abstract
Herpesvirus saimiri encodes a functional homolog of human regulator-of-complement-activation proteins named CCPH that inactivates complement by accelerating the decay of C3 convertases and by serving as a cofactor in factor I-mediated inactivation of their subunits C3b and C4b. Here, we map the functional domains of CCPH. We demonstrate that short consensus repeat 2 (SCR2) is the minimum domain essential for classical/lectin pathway C3 convertase decay-accelerating activity as well as for factor I cofactor activity for C3b and C4b. Thus, CCPH is the first example wherein a single SCR domain has been shown to display complement regulatory functions.
Item Type: | Article |
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Source: | Copyright of this article belongs to American Society for Microbiology. |
ID Code: | 123307 |
Deposited On: | 13 Sep 2021 08:14 |
Last Modified: | 13 Sep 2021 08:14 |
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