Ojha, Hina ; Panwar, Hemendra Singh ; Gorham, Ronald D. ; Morikis, Dimitrios ; Sahu, Arvind (2014) Viral regulators of complement activation: Structure, function and evolution Molecular Immunology, 61 (2). pp. 89-99. ISSN 0161-5890
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Official URL: http://doi.org/10.1016/j.molimm.2014.06.004
Related URL: http://dx.doi.org/10.1016/j.molimm.2014.06.004
Abstract
The complement system surveillance in the host is effective in controlling viral propagation. Consequently, to subvert this effector mechanism, viruses have developed a series of adaptations. One among these is encoding mimics of host regulators of complement activation (RCA) which help viruses to avoid being labeled as ‘foreign’ and protect them from complement-mediated neutralization and complement-enhanced antiviral adaptive immunity. In this review, we provide an overview on the structure, function and evolution of viral RCA proteins.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 123296 |
| Deposited On: | 13 Sep 2021 07:21 |
| Last Modified: | 13 Sep 2021 07:21 |
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