Direct Access to Benzo[b]furans through Palladium-Catalyzed Oxidative Annulation of Phenols and Unactivated Internal Alkynes

Kuram, Malleswara Rao ; Bhanuchandra, M. ; Sahoo, Akhila K. (2013) Direct Access to Benzo[b]furans through Palladium-Catalyzed Oxidative Annulation of Phenols and Unactivated Internal Alkynes Angewandte Chemie International Edition, 52 (17). pp. 4607-4612. ISSN 1433-7851

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Official URL: http://doi.org/10.1002/anie.201210217

Related URL: http://dx.doi.org/10.1002/anie.201210217

Abstract

2,3-Disubstituted benzo[b]furans are prepared in one step from commercially available phenols and readily accessible unactivated internal alkynes (see scheme). This Pd-catalyzed oxidative annulation has a broad substrate scope and allows access to a wide range of benzo[b]furans.

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