Rit, Raja K. ; Yadav, M. Ramu ; Ghosh, Koushik ; Shankar, Majji ; Sahoo, Akhila K. (2014) Sulfoximine Assisted Pd(II)-Catalyzed Bromination and Chlorination of Primary β-C(sp3)–H Bond Organic Letters, 16 (20). pp. 5258-5261. ISSN 1523-7060
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Official URL: http://doi.org/10.1021/ol502337b
Related URL: http://dx.doi.org/10.1021/ol502337b
Abstract
S-Methyl-S-2-pyridyl-sulfoximine (MPyS) directed bromination and chlorination of the 1°-β-C(sp3)–H bond of MPyS-N-amides is realized under the influence of N-Br/Cl-phthalimides and a Pd(II)-catalyst. The sequential halogenation and acetoxylation of α-dimethyl MPyS-N-amides constructs highly functionalized α-trisubstituted aliphatic acid derivatives. The MPyS directing group is cleaved from the halogenated products and recovered.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 122444 |
| Deposited On: | 02 Aug 2021 14:44 |
| Last Modified: | 02 Aug 2021 14:44 |
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