Yadav, M. Ramu ; Shankar, Majji ; Ramesh, E. ; Ghosh, Koushik ; Sahoo, Akhila K. (2015) Ruthenium-Catalyzed ortho-C–H Mono- and Di-imidation of Arenes with N-Tosyloxyphthalimide Organic Letters, 17 (8). pp. 1886-1889. ISSN 1523-7060
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Official URL: http://doi.org/10.1021/acs.orglett.5b00570
Related URL: http://dx.doi.org/10.1021/acs.orglett.5b00570
Abstract
The Ru(II)-catalyzed imidation of the o-C–H bond in arenes with N-tosyloxyphthalimide is realized with the assistance of a methyl phenylsulfoximine (MPS) directing group. This method is applicable to access the hitherto difficult o-C–H di-imidation products. The sequential C–N and C–C bond formation of o-C–H arenes creates peripherally decorated benzoic acid derivatives. The readily removable MPS-DG and easily modifiable phthaloyl moiety make this strategy synthetically viable for constructing highly functionalized C–N bearing arenes and heteroarenes.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 122443 |
| Deposited On: | 02 Aug 2021 14:40 |
| Last Modified: | 02 Aug 2021 14:40 |
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