Ramanathan, Senthil Kumar ; Keeler, John ; Lee, Huey-Lih ; Reddy, D. Srinavasa ; Lushington, Gerald ; Aubé, Jeffrey (2005) Modular Synthesis of Cyclic Peptidomimetics Inspired by γ-Turns† Organic Letters, 7 (6). pp. 1059-1062. ISSN 1523-7060
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Official URL: http://doi.org/10.1021/ol047323a
Related URL: http://dx.doi.org/10.1021/ol047323a
Abstract
A series of peptidomimetics based on a γ-turn motif were synthesized using a modular approach, in which N-protected piperidones were reacted with a selection of 2-hydroxyalkyl azides derived from common l-amino acids. Hydrolysis of the initially formed iminium ethers afforded the targeted series of substituted 1,4-diazepin-5-ones.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society |
| ID Code: | 122022 |
| Deposited On: | 27 Jul 2021 10:17 |
| Last Modified: | 27 Jul 2021 10:17 |
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