Sapru, R. P. ; Moza, A. K. ; Kumar, M. ; Ganguly, N. K. (1975) Antibodies to Arvin following prolonged intravenous therapy Thrombosis Research: Vascular Obstruction, Hemorrhage and Hemostasis, 7 (4). pp. 635-641. ISSN 0049-3848
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/004938...
Related URL: http://dx.doi.org/10.1016/0049-3848(75)90109-7
Abstract
Intravenous administration of Arvin in rabbits over a period of two months produced antibodies with consequent neutralisation of its action and a rise in fibrinogen concentration of blood to control values. The antibodies could be detected by the end of four weeks of therapy and were found to be a mixture of lgG and lgM class of immunoglobulins. The results indicate that prolonged Arvin therapy in clinical disorders may not be possible because of the antibody response to the drug.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 12201 |
| Deposited On: | 10 Nov 2010 04:39 |
| Last Modified: | 31 May 2011 11:33 |
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