Total Synthesis of Isofregenedadiol#

Kurhade, Suresh E. ; Sanchawala, Abbas I. ; Ravikumar, Velayutham ; Bhuniya, Debnath ; Reddy, D. Srinivasa (2011) Total Synthesis of Isofregenedadiol# Organic Letters, 13 (14). pp. 3690-3693. ISSN 1523-7060

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Official URL: http://doi.org/10.1021/ol201336x

Related URL: http://dx.doi.org/10.1021/ol201336x

Abstract

The first total synthesis of isofregenedadiol, a bicyclic diterpene isolated from H. Viscosum, is reported starting from a d-(−)-pantolactone chiral pool. A one-pot quadruple reaction sequence comprising an enyne ring-closing metathesis/cross-metathesis/Diels–Alder/aromatization for the construction of a target skeleton is the highlight of the present synthesis.

Item Type:Article
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ID Code:122001
Deposited On:27 Jul 2021 08:55
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