Studies toward the Synthesis of Potent Anti-inflammatory Peptides Solomonamides A and B: Synthesis of a Macrocyclic Skeleton and Key Fragment 4-Amino-6-(2′-amino-4′-hydroxyphenyl)-3-hydroxy-2-methyl-6-oxohexanoic Acid (AHMOA)

Kashinath, K. ; Vasudevan, N. ; Reddy, D. Srinivasa (2012) Studies toward the Synthesis of Potent Anti-inflammatory Peptides Solomonamides A and B: Synthesis of a Macrocyclic Skeleton and Key Fragment 4-Amino-6-(2′-amino-4′-hydroxyphenyl)-3-hydroxy-2-methyl-6-oxohexanoic Acid (AHMOA) Organic Letters, 14 (24). pp. 6222-6225. ISSN 1523-7060

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Official URL: http://doi.org/10.1021/ol303149k

Related URL: http://dx.doi.org/10.1021/ol303149k

Abstract

A first synthetic effort toward total synthesis of highly potent solomonamides is disclosed. An efficient strategy to synthesize this class of compounds, along with the synthesis of a core macrocycle (shown in red) and the key fragment AHMOA, is described.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society
ID Code:121995
Deposited On:27 Jul 2021 08:43
Last Modified:27 Jul 2021 08:43

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