First Total Synthesis of Hunanamycin A

Shingare, Rahul D. ; Velayudham, R. ; Gawade, Jalindar R. ; Reddy, D. Srinivasa (2013) First Total Synthesis of Hunanamycin A Organic Letters, 15 (17). pp. 4556-4559. ISSN 1523-7060

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Official URL: http://doi.org/10.1021/ol402110e

Related URL: http://dx.doi.org/10.1021/ol402110e

Abstract

The first total synthesis of hunanamycin A, an antibiotic natural product with a pyrido[1,2,3-de]quinoxaline-2,3-dione core from a marine-derived Bacillus hunanensis, is disclosed. The present effort provides access to sufficient amounts of scarce hunanamycin A for further biological evaluation and confirmation of the assigned absolute configuration. In addition, four new analogues of the natural product are reported.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society
ID Code:121959
Deposited On:23 Jul 2021 10:21
Last Modified:23 Jul 2021 10:21

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