First Total Synthesis of Gliomasolide C and Formal Total Synthesis of Sch-725674

Seetharamsingh, B. ; Khairnar, Pankaj V. ; Reddy, D. Srinivasa (2016) First Total Synthesis of Gliomasolide C and Formal Total Synthesis of Sch-725674 Journal of Organic Chemistry, 81 (1). pp. 290-296. ISSN 0022-3263

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Official URL: http://doi.org/10.1021/acs.joc.5b02318

Related URL: http://dx.doi.org/10.1021/acs.joc.5b02318

Abstract

Syntheses of two 14-membered macrolides Sch-725674 and Gliomasolide C are described here. The first total synthesis of Gliomasolide C, the short synthesis of Sch-725674, and regioselective Wacker oxidation of internal olefin are the highlights of this disclosure. In addition, a key macrocycle with orthogonal functionalities was designed and synthesized on a gram scale for the generation of analogues.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society
ID Code:121938
Deposited On:23 Jul 2021 08:55
Last Modified:23 Jul 2021 08:55

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