Seetharamsingh, B. ; Ganesh, Routholla ; Reddy, D. Srinivasa (2017) Determination of the Absolute Configuration of Gliomasolide D through Total Syntheses of the C-17 Epimers Journal of Natural Products, 80 (2). pp. 560-564. ISSN 0163-3864
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Official URL: http://doi.org/10.1021/acs.jnatprod.6b00926
Related URL: http://dx.doi.org/10.1021/acs.jnatprod.6b00926
Abstract
The absolute configuration at C-17, the carbon bearing the distal hydroxy group of the 14-membered natural product gliomasolide D, was assigned as R by comparison of 13C NMR shifts and specific rotation values of the epimers at C-17. The first total synthesis of gliomasolide D along with its C-17 epimer, regioselective macrocyclization (18 membered vs 14 membered), and regioselective Wacker oxidation are highlights of the present work.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society |
| ID Code: | 121928 |
| Deposited On: | 23 Jul 2021 08:22 |
| Last Modified: | 23 Jul 2021 08:22 |
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