Kalmode, Hanuman P. ; Handore, Kishor L. ; Reddy, D. Srinivasa (2017) Access to Fused Tricyclic γ-Butyrolactones, A Natural Product-like Scaffold Journal of Organic Chemistry, 82 (14). pp. 7614-7620. ISSN 0022-3263
Full text not available from this repository.
Official URL: http://doi.org/10.1021/acs.joc.7b00794
Related URL: http://dx.doi.org/10.1021/acs.joc.7b00794
Abstract
Serendipitous findings of an acid mediated skeletal rearrangement of bicyclo-β-ketoester having cyclopropyl ring to access fused tricyclic γ-butyrolactones has been described. This novel transformation has been optimized to 30 mol% p-toluenesulfonic acid (p-TSA) in toluene using Dean–Stark apparatus, where the aldol condensation, cyclopropyl ring opening followed by cyclization took place in a single-pot operation. The resulting tricyclic compounds are interesting chemotype with natural product resemblance and may find useful applications in the future.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society |
| ID Code: | 121924 |
| Deposited On: | 23 Jul 2021 08:06 |
| Last Modified: | 23 Jul 2021 08:06 |
Repository Staff Only: item control page
