Rit, Raja K. ; Ghosh, Koushik ; Mandal, Rajib ; Sahoo, Akhila K. (2016) Ruthenium-Catalyzed Intramolecular Hydroarylation of Arenes and Mechanistic Study: Synthesis of Dihydrobenzofurans, Indolines, and Chromans Journal of Organic Chemistry, 81 (18). pp. 8552-8560. ISSN 0022-3263
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Official URL: http://doi.org/10.1021/acs.joc.6b01734
Related URL: http://dx.doi.org/10.1021/acs.joc.6b01734
Abstract
A ruthenium-catalyzed, amide-directed intramolecular hydroarylation of alkene-tethered benzamide derivatives is discussed. This method proficiently constructs dihydrobenzofuran, indoline, and chroman skeletons of biological significance in good to excellent yields; the overall process is atom-economical and step-efficient. The reaction exhibits broad scope, tolerating common functional groups, labile protecting units, and heteroaryl motifs. The use of a catalytic amount of base suffices the need. Deuterium scrambling and kinetic studies offer valuable facts for understanding the reaction mechanism.
Item Type: | Article |
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Source: | Copyright of this article belongs to American Chemical Society. |
ID Code: | 121876 |
Deposited On: | 22 Jul 2021 19:15 |
Last Modified: | 22 Jul 2021 19:15 |
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