Thakare, Ritesh ; Singh, Alok Kumar ; Das, Swetarka ; Vasudevan, N. ; Jachak, Gorakhnath R. ; Reddy, D. Srinivasa ; Dasgupta, Arunava ; Chopra, Sidharth (2017) Repurposing Ivacaftor for treatment of Staphylococcus aureus infections International Journal of Antimicrobial Agents, 50 (3). pp. 389-392. ISSN 0924-8579
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Official URL: http://doi.org/10.1016/j.ijantimicag.2017.03.020
Related URL: http://dx.doi.org/10.1016/j.ijantimicag.2017.03.020
Abstract
Drug repurposing of non-antimicrobials is a novel method to augment a seriously depleted drug pipeline for targeting drug-resistant pathogens. This article highlights the potent antimicrobial activity of Ivacaftor against Staphylococcus aureus, including vancomycin- and other multidrug-resistant strains. The potent activity of Ivacaftor in vivo is also demonstrated in a murine neutropenic thigh infection model. Taken together, these results support the potential of Ivacaftor as an antimicrobial agent for the treatment of staphylococcal infections.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to National Library of Medicine |
| ID Code: | 121865 |
| Deposited On: | 22 Jul 2021 15:17 |
| Last Modified: | 30 Jul 2021 07:32 |
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