Athawale, Paresh R. ; Jachak, Gorakhnath R. ; Shukla, Anurag ; Shanmugam, Dhanasekaran ; Reddy, D. Srinivasa (2018) Efforts To Access the Potent Antitrypanosomal Marine Natural Product Janadolide: Synthesis of Des-tert-butyl Janadolide and Its Biological Evaluation ACS Omega, 3 (2). pp. 2383-2389. ISSN 2470-1343
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Official URL: http://doi.org/10.1021/acsomega.7b01920
Related URL: http://dx.doi.org/10.1021/acsomega.7b01920
Abstract
To identify novel antitrypanosomal agents based on Janadolide, a potent macrocyclic polyketide–peptide hybrid, a macrolactonization strategy was explored. We prepared des-tert-butyl Janadolide and evaluated its antitrypanosomal activity. Our findings suggest that the tert-butyl group is necessary for the desired bioactivity.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society |
| ID Code: | 121864 |
| Deposited On: | 22 Jul 2021 15:12 |
| Last Modified: | 22 Jul 2021 15:12 |
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