Efforts To Access the Potent Antitrypanosomal Marine Natural Product Janadolide: Synthesis of Des-tert-butyl Janadolide and Its Biological Evaluation

Athawale, Paresh R. ; Jachak, Gorakhnath R. ; Shukla, Anurag ; Shanmugam, Dhanasekaran ; Reddy, D. Srinivasa (2018) Efforts To Access the Potent Antitrypanosomal Marine Natural Product Janadolide: Synthesis of Des-tert-butyl Janadolide and Its Biological Evaluation ACS Omega, 3 (2). pp. 2383-2389. ISSN 2470-1343

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Official URL: http://doi.org/10.1021/acsomega.7b01920

Related URL: http://dx.doi.org/10.1021/acsomega.7b01920

Abstract

To identify novel antitrypanosomal agents based on Janadolide, a potent macrocyclic polyketide–peptide hybrid, a macrolactonization strategy was explored. We prepared des-tert-butyl Janadolide and evaluated its antitrypanosomal activity. Our findings suggest that the tert-butyl group is necessary for the desired bioactivity.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society
ID Code:121864
Deposited On:22 Jul 2021 15:12
Last Modified:22 Jul 2021 15:12

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