Jachak, Gorakhnath R. ; Reddy, D. Srinivasa (2018) Scalable Synthesis of Both Enantiomers of Vigabatrin, an Antiepileptic Drug European Journal of Organic Chemistry, 2019 (6). pp. 1257-1260. ISSN 1434193X
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Official URL: http://doi.org/10.1002/ejoc.201801617
Related URL: http://dx.doi.org/10.1002/ejoc.201801617
Abstract
Vigabatrin is a potent inhibitor of gamma-aminobutyric acid (GABA) catabolism used for the treatment of epilepsy. Here we have synthesized both enantiomers of the drug vigabatrin in five steps from known intermediates using Wittig olefination and pyrolytic elimination as key steps. The target compounds are synthesized in gram scale amounts with >98 % enantiopurity.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to About Wiley Online Library |
| ID Code: | 121818 |
| Deposited On: | 22 Jul 2021 10:07 |
| Last Modified: | 22 Jul 2021 10:07 |
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