Gunjal, Vidya B. ; Reddy, D. Srinivasa (2019) Total synthesis of Met10-teixobactin Tetrahedron Letters, 60 (29). pp. 1909-1912. ISSN 00404039
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Official URL: http://doi.org/10.1016/j.tetlet.2019.06.027
Related URL: http://dx.doi.org/10.1016/j.tetlet.2019.06.027
Abstract
The total synthesis of cyclic depsipeptide Met10-teixobactin in solution-phase is described. Teixobactin is a structurally and mechanistically novel antimicrobial peptidic natural product with very impressive activities against Gram-positive pathogens. It happens to possess an l-allo-enduracididine (End) residue as part of macrocyclic ring which is not readily accessible. In this report, we have used serine ligation strategy as the key step to prepare an analogue of teixobactin where End being replaced with a readily available amino acid methionine.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier B.V |
| ID Code: | 121814 |
| Deposited On: | 22 Jul 2021 09:49 |
| Last Modified: | 22 Jul 2021 09:49 |
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