Narayanan, Rishikesh ; Dougherty, Kevin J. ; Johnston, Daniel (2010) Calcium Store Depletion Induces Persistent Perisomatic Increases in the Functional Density of h Channels in Hippocampal Pyramidal Neurons Neuron, 68 (5). pp. 921-935. ISSN 0896-6273
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Official URL: http://doi.org/10.1016/j.neuron.2010.11.033
Related URL: http://dx.doi.org/10.1016/j.neuron.2010.11.033
Abstract
The regulation of intracellular calcium by the endoplasmic reticulum (ER) plays a critical role in neuronal function. While the consequences associated with depleting calcium from the ER have been studied in multiple systems, it is not known whether the intrinsic properties of a neuron change in response to such perturbations. In this study, we demonstrate that the depletion of calcium from the ER of hippocampal CA1 pyramidal neurons induces a persistent, perisomatic increase in the density of functional h channels resulting in a reduction in intrinsic excitability and an increase in the optimal response frequency. This form of intrinsic plasticity is dependent on the elevation of cytoplasmic calcium, inositol triphosphate receptors, store-operated calcium channels, and the protein kinase A pathway. We postulate that this form of depletion-induced intrinsic plasticity is a neuroprotective mechanism that reduces excitability after depletion of calcium stores triggered through altered network activity during pathological conditions.
Item Type: | Article |
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Source: | Copyright of this article belongs to Cell Press Inc. |
ID Code: | 121740 |
Deposited On: | 21 Jul 2021 12:30 |
Last Modified: | 21 Jul 2021 12:30 |
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