Jain, Abha ; Narayanan, Rishikesh (2020) Degeneracy in the emergence of spike-triggered average of hippocampal pyramidal neurons Scientific Reports, 10 (1). ISSN 2045-2322
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Official URL: http://doi.org/10.1038/s41598-019-57243-8
Related URL: http://dx.doi.org/10.1038/s41598-019-57243-8
Abstract
Hippocampal pyramidal neurons are endowed with signature excitability characteristics, exhibit theta-frequency selectivity — manifesting as impedance resonance and as a band-pass structure in the spike-triggered average (STA) — and coincidence detection tuned for gamma-frequency inputs. Are there specific constraints on molecular-scale (ion channel) properties in the concomitant emergence of cellular-scale encoding (feature detection and selectivity) and excitability characteristics? Here, we employed a biophysically-constrained unbiased stochastic search strategy involving thousands of conductance-based models, spanning 11 active ion channels, to assess the concomitant emergence of 14 different electrophysiological measurements. Despite the strong biophysical and physiological constraints, we found models that were similar in terms of their spectral selectivity, operating mode along the integrator-coincidence detection continuum and intrinsic excitability characteristics. The parametric combinations that resulted in these functionally similar models were non-unique with weak pair-wise correlations. Employing virtual knockout of individual ion channels in these functionally similar models, we found a many-to-many relationship between channels and physiological characteristics to mediate this degeneracy, and predicted a dominant role for HCN and transient potassium channels in regulating hippocampal neuronal STA. Our analyses reveals the expression of degeneracy, that results from synergistic interactions among disparate channel components, in the concomitant emergence of neuronal excitability and encoding characteristics.
Item Type: | Article |
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Source: | Copyright of this article belongs to Nature Publishing Group. |
ID Code: | 121705 |
Deposited On: | 21 Jul 2021 10:31 |
Last Modified: | 21 Jul 2021 10:31 |
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