Thomas Pucadyil: Piecing together membrane fission

Abstract

Pucadyil investigates membrane fission using novel model membrane systems. Molecules from outside the cell, or those produced inside the cell, can be packed into membrane-bound vesicles to facilitate their transport to different cellular compartments. This is a highly regulated process that remains poorly understood, even at the most basic level; it is still unclear, for instance, how vesicles form and bud off from their parent membrane.