Reactive oxygen intermediates and reactive nitrogen intermediates in copper intrauterine device users

Anjalika, ; Gupta, I. ; Gupta, Sushil K. ; Ganguly, Nirmal K. (1999) Reactive oxygen intermediates and reactive nitrogen intermediates in copper intrauterine device users Contraception, 59 (1). pp. 67-70. ISSN 0010-7824

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Official URL: http://dx.doi.org//10.1016/S0010-7824(98)00143-7

Related URL: http://dx.doi.org/10.1016/S0010-7824(98)00143-7

Abstract

The mechanism of action of copper in copper intrauterine devices (Cu IUD) as an antimicrobial agent is not well understood. Copper and iron are supposed to be responsible for release of reactive oxygen intermediates (ROI) and reactive nitrogen intermediates (RNI), which are very active in the presence of infection. The copper in a copper IUD could be responsible for limiting pelvic inflammatory disease. The present study was composed of 20 IUD seekers in whom ROI and RNI were studied before insertion of Cu IUD and then at 1, 4, and 12 weeks afterward. ROI showed a rise after insertion, whereas RNI showed a steady decline. Hence, it is presumed that the rise in ROI could be responsible for both the bactericidal effect of Cu IUD and also for the fall in RNI.

Item Type:Article
Source:Copyright of this article belongs to Association of Reproductive Health Professionals.
Keywords:Toxic Metabolites; Polymorphonuclear Leukocytes in Endometrium
ID Code:12166
Deposited On:10 Nov 2010 04:11
Last Modified:31 May 2011 10:24

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