Nair, Divya K. ; Mobin, Shaikh M. ; Namboothiri, Irishi N. N. (2012) Synthesis of Imidazopyridines from the Morita–Baylis–Hillman Acetates of Nitroalkenes and Convenient Access to Alpidem and Zolpidem Organic Letters, 14 (17). pp. 4580-4583. ISSN 1523-7060
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Official URL: http://doi.org/10.1021/ol3020418
Related URL: http://dx.doi.org/10.1021/ol3020418
Abstract
A variety of functionalized imidazo[1,2-a]pyridines have been synthesized through a one-pot, room temperature, and reagent-free reaction between MBH acetates of nitroalkenes and 2-aminopyridines. The reaction involves a cascade inter-intramolecular double aza-Michael addition of 2-aminopyridines to MBH acetates. Our methodology is marked by excellent yield, regioselectivity and, above all, adaptability to synthesize imidazopyridine-based drug molecules such as Alpidem and Zolpidem.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 121559 |
| Deposited On: | 19 Jul 2021 08:55 |
| Last Modified: | 19 Jul 2021 08:55 |
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