Gupta, R. ; Gupta, S. ; Joshi, K. ; Ganguly, N. K. (1997) Role of iron and iron chelation therapy in oxygen free radical mediated tissue injury in an ascending mouse model of chronic pyelonephritis Comparative Immunology, Microbiology and Infectious Diseases, 20 (4). pp. 299-307. ISSN 0147-9571
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S01479...
Related URL: http://dx.doi.org/10.1016/S0147-9571(97)00001-5
Abstract
The contribution of iron towards the free radical generation leading to renal tissue damage was assessed using a non-obstructive ascending mouse model for chronic pyelonephritis. The parameters studied include luminol dependent chemiluminescence (LDCL), histopathology and some biochemical investigations. We found that iron enhanced the renal tissue damage and led to renal scarring, an end point in chronic renal inflammation, irrespective of the bacterial strain studied. In addition a role of iron chelation therapy as a treatment for chronic renal inflammation is also suggested.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Author Keywords: Pyelonephritis; Ascending Route; Reactive Oxygen Species; Iron Chelation; Iron Overload; Lipid Peroxidation; LDCL; Enzyme |
| ID Code: | 12153 |
| Deposited On: | 10 Nov 2010 04:07 |
| Last Modified: | 31 May 2011 10:26 |
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