Gopi, Elumalai ; Kumar, Tarun ; Menna-Barreto, Rubem F. S. ; Valença, Wagner O. ; da Silva Júnior, Eufrânio N. ; Namboothiri, Irishi N. N. (2015) Imidazoles from nitroallylic acetates and α-bromonitroalkenes with amidines: synthesis and trypanocidal activity studies Organic and Biomolecular Chemistry, 13 (38). pp. 9862-9871. ISSN 1477-0520
Full text not available from this repository.
Official URL: http://doi.org/10.1039/c5ob01444a
Related URL: http://dx.doi.org/10.1039/c5ob01444a
Abstract
Cascade reactions of amidines with nitroallylic acetates and α-bromonitroalkenes provide potentially bioactive imidazoles in good to excellent yields in most cases. While 2,4-disubstituted imidazol-5-yl acetates are formed in the first case, 2,4-disubstituted imidazoles, bearing no substituent at position 5, are the products in the second case. These two series of imidazoles, viz. 2,4,5-trisubstituted and 2,4-disubstituted, were screened for their activity against the protozoan parasite Trypanosoma cruzi which is responsible for Chagas disease. As many as three compounds were as active as the standard benznidazole and two others were 2-3-fold more active highlighting the potential of substituted imidazoles, easily accessible from nitroalkenes, as possible anti-parasitic agents.
Item Type: | Article |
---|---|
Source: | Copyright of this article belongs to The Royal Society of Chemistry. |
ID Code: | 121391 |
Deposited On: | 15 Jul 2021 11:59 |
Last Modified: | 15 Jul 2021 11:59 |
Repository Staff Only: item control page