Kanwar, Rupinder Kaur ; Ganguly, N. K. ; Kanwar, J. R. ; Kumar, Lata ; Walia, B. N. S. (1994) Impairment of Na+,K+-ATPase activity following enterotoxigenic Campylobacter jejuni infection: changes in Na+, Cl- and 3-O-methyl-D-glucose transport in vitro, in rat ileum FEMS Microbiology Letters, 124 (3). pp. 381-385. ISSN 0378-1097
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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1574-...
Related URL: http://dx.doi.org/10.1111/j.1574-6968.1994.tb07312.x
Abstract
Unidirectional fluxes of Na+, Cl- and 3-O-methyl-D-glucose (3-MG) were measured in vitro across Campylobacter jejuni live culture-infected and control rat ileal short-circuited tissues by the Using Chamber technique. Net secretion of Na+ and enhanced secretion of Cl- ions was observed in the infected animals (P < 0.001, n=6) as compared to the net absorption of Na+ and marginal secretion of Cl- ions in the control animals. There was a significant decrease in the mucosal-to-serosal fluxes of 3-MG in C. jejuni-infected rat ileum. The specific Na+,K+-ATPase activity when measured biochemically in the membrane-rich fraction of enterocytes was found to be significantly lower (58%) in the infected group as compared to the control group (P < 0.001). Our results therefore suggest that infection with an enterotoxigenic C. jejuni inhibits the Na+,K+-ATPase activity in rat enterocytes. The impairment of Na+,K+-ATPase activity thus appears to induce a secondary change in Na+,Cl- and 3-MG transport in vitro in rat ileum.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons, Inc. |
| Keywords: | Campylobacter Jejuni; Na+; K+-Atpase; Intestinal Electrolyte Secretion; Diarrhoea; Sugar Transport |
| ID Code: | 12136 |
| Deposited On: | 10 Nov 2010 04:18 |
| Last Modified: | 31 May 2011 10:31 |
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