Reddy, Pranathi A. ; Gupta, Indu ; Ganguly, N. K. (1994) Hepatitis-B vaccination in pregnancy: safety and immunogenic response in mothers and antibody transfer to neonates Asia-Oceania Journal of Obstetrics and Gynaecology, 20 (4). pp. 361-365. ISSN 0389-2328
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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1447-...
Related URL: http://dx.doi.org/10.1111/j.1447-0756.1994.tb00482.x
Abstract
Hepatitis B infection during pregnancy causes increased, maternal morbidity and perinatal mortality. No specific therapy is available, hence neonatal immuno-prophylaxis is recommended by WHO. However, the advantages of maternal immunization are manifold. Therefore, 15 pregnant HBsAg negative women were studied after 3 dozes of hepatitis B specific vaccine. No untoward effects of vaccine were observed and a good immunogenic response with very high antibody titres 178 IU/ l and 184 IU/l at delivery and 3 months post delivery respectively were noted. Passive transfer of antibodies to the neonates was 100% at birth but these levels declined rapidly. Hence hepatitis B specific vaccine is safe and immunogenic in pregnant women and protects their babies in the immediate neonatal period.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Japanese Society of Obstetrics and Gynaecology. |
| Keywords: | Hepatitis B Vaccination; Immunogenicity Antibody Transfer |
| ID Code: | 12134 |
| Deposited On: | 10 Nov 2010 04:18 |
| Last Modified: | 31 May 2011 10:31 |
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