Sharma, S. ; Garg, U. C. ; Ganguly, N. K. ; Sharma, B. K. (1987) Effect of iron on early changes in Escherichia coli-induced ascending pyelonephritis in rats FEMS Microbiology Letters, 41 (3). pp. 295-298. ISSN 0378-1097
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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1574-...
Related URL: http://dx.doi.org/10.1111/j.1574-6968.1987.tb02214.x
Abstract
Uptake of D-glucose, L-lysine and L-proline and the kinetic parameters of alkaline phosphatase and γ-glutamyl-transpeptidase were evaluated in renal brush border membrane (BBM) vesicles prepared from control, pyelonephritic and iron-administered pyelonephritic rats. The uptake of D-glucose and amino acids and Vmax of both the enzymes studied were found to be altered in pyelonephritic and iron-administered pyelonephritic rats, but changes appeared earlier and more severely in iron-administered infected animals than in other infected animals. These early physiological alterations were accompanied by higher bacterial colonisation in iron-administered rats.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons, Inc. |
| Keywords: | Iron;escherichia Coli; Pyelonephritis; Virulence Factor; (Rat) |
| ID Code: | 12133 |
| Deposited On: | 10 Nov 2010 04:19 |
| Last Modified: | 31 May 2011 11:23 |
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