Bera, Kalisankar ; Satam, Nishikant S. ; Namboothiri, Irishi N. N. (2016) Enantioselective Synthesis of Quaternary α-Amino Acids via l-tert-Leucine-Derived Squaramide-Catalyzed Conjugate Addition of α-Nitrocarboxylates to Enones Journal of Organic Chemistry, 81 (13). pp. 5670-5680. ISSN 0022-3263
Full text not available from this repository.
Official URL: http://doi.org/10.1021/acs.joc.6b00543
Related URL: http://dx.doi.org/10.1021/acs.joc.6b00543
Abstract
Enantioselective Michael addition of tertiary α-nitroesters to β-unsubstituted vinyl ketones has been carried out in the presence of an l-tert-leucine-derived squaramide as organocatalyst. The products, quaternary α-nitroesters, were formed in excellent yield and moderate to good ee's in most cases. Scale-up of the reaction and synthetic applications of the products, including transformation to representative quaternary α-amino acids, have also been demonstrated.
Item Type: | Article |
---|---|
Source: | Copyright of this article belongs to American Chemical Society. |
Keywords: | Catalysts; Hydrocarbons; Aromatic Compounds; Stereoselectivity; Enones. |
ID Code: | 121321 |
Deposited On: | 14 Jul 2021 09:50 |
Last Modified: | 14 Jul 2021 09:50 |
Repository Staff Only: item control page