Ramachary, Dhevalapally B. ; Barbas, Carlos F. (2005) Direct Amino Acid-Catalyzed Asymmetric Desymmetrization ofmeso-Compounds: Tandem Aminoxylation/O−N Bond Heterolysis Reactions Organic Letters, 7 (8). pp. 1577-1580. ISSN 1523-7060
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Official URL: http://doi.org/10.1021/ol050246e
Related URL: http://dx.doi.org/10.1021/ol050246e
Abstract
A practical organocatalytic process for the synthesis of optically active, highly substituted α-hydroxy-ketones was achieved through asymmetric desymmetrization (ADS) of prochiral ketones. The ADS and O−N bond reduction reaction of prochiral ketone with nitrosobenzene in the presence of a catalytic amount of chiral amine or amino acid produced the tandem ADS/O−N bond reduced products as single diastereomers with good yields and excellent enantiomeric excesses.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 120802 |
| Deposited On: | 05 Jul 2021 12:00 |
| Last Modified: | 05 Jul 2021 12:00 |
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