Barbas III, Carlos F. ; Chowdari, Naidu S. ; Ramachary, D. B. (2003) Organocatalysis in Ionic Liquids: Highly Efficientl-Proline-Catalyzed Direct Asymmetric Mannich Reactions Involving Ketone and Aldehyde Nucleophiles Synlett (12). pp. 1906-1909. ISSN 0936-5214
Full text not available from this repository.
Official URL: http://doi.org/10.1055/s-2003-41483
Related URL: http://dx.doi.org/10.1055/s-2003-41483
Abstract
Proline-catalyzed direct asymmetric Mannich reactions of N-PMP protected α-imino ethyl glyoxylate with various aldehydes and ketones in ionic liquids afforded both α- and β-amino acid derivatives with excellent yields and enantioselectivities, providing facile product isolation, catalyst recycling, and significantly improved reaction rates, ca 4- to 50-fold. Three component Mannich reactions involving other imines also worked well in ionic liquids. Significant advantages and limitations of ionic liquid solvents in this reaction have been revealed.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Thieme Medical Publishers Inc. |
| ID Code: | 120795 |
| Deposited On: | 05 Jul 2021 11:37 |
| Last Modified: | 05 Jul 2021 11:37 |
Repository Staff Only: item control page
