Amine-catalyzed direct self Diels–Alder reactions of α,β-unsaturated ketones in water: synthesis of pro-chiral cyclohexanones

Ramachary, D.B. ; Chowdari, Naidu S. ; Barbas, Carlos F. (2002) Amine-catalyzed direct self Diels–Alder reactions of α,β-unsaturated ketones in water: synthesis of pro-chiral cyclohexanones Tetrahedron Letters, 43 (38). pp. 6743-6746. ISSN 0040-4039

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Official URL: http://doi.org/10.1016/S0040-4039(02)01500-9

Related URL: http://dx.doi.org/10.1016/S0040-4039(02)01500-9

Abstract

Amine-catalyzed direct self Diels–Alder reactions of α,β-unsaturated ketones have been developed. (S)-1-(2-Pyrrolidinyl-methyl)pyrrolidine, l-proline and pyrrolidine catalyzed the reaction of α,β-unsaturated ketones to provide cyclohexanone derivatives with good yield (up to 80%) in a single step via in situ-generation of 2-amino-1,3-butadienes and iminium ion-activated enones. Pro-chiral cyclohexanones were selectively prepared with pyrrolidine catalysis in water.

Item Type:Article
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ID Code:120792
Deposited On:05 Jul 2021 11:30
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