Development of drug intermediates by using direct organocatalytic multi-component reactions

Ramachary, Dhevalapally B. ; Kishor, M. ; Reddy, G. Babul (2006) Development of drug intermediates by using direct organocatalytic multi-component reactions Organic and Biomolecular Chemistry, 4 (9). p. 1641. ISSN 1477-0520

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Official URL: http://doi.org/10.1039/B602696F

Related URL: http://dx.doi.org/10.1039/B602696F

Abstract

Novel, economic and environmentally friendly one-pot three-component Knoevenagel/hydrogenation (K/H) and four-component Knoevenagel/hydrogenation/alkylation (K/H/A) reactions of ketones, CH-acids, dihydropyridines and alkyl halides using proline and proline/metal carbonate catalysis, respectively, have been developed. Many of the products of these K/H and K/H/A reactions have direct applications in pharmaceutical chemistry.

Item Type:Article
Source:Copyright of this article belongs to The Royal Society of Chemistry.
ID Code:120786
Deposited On:05 Jul 2021 07:55
Last Modified:05 Jul 2021 07:55

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