Ramachary, Dhevalapally B. ; Shiva Prasad, M. (2010) Direct amino acid-catalyzed cascade reductive alkylation of arylacetonitriles: high-yielding synthesis of ibuprofen analogs Tetrahedron Letters, 51 (40). pp. 5246-5251. ISSN 0040-4039
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Official URL: http://doi.org/10.1016/j.tetlet.2010.07.131
Related URL: http://dx.doi.org/10.1016/j.tetlet.2010.07.131
Abstract
A novel approach for a one-pot, three-component reductive alkylation (TCRA) reaction of arylacetonitriles-containing electron-withdrawing groups with aldehydes/ketones and 1,4-dihydropyridine via iminium-catalysis has been developed. Many TCRA reaction products have direct applications in agricultural and pharmaceutical chemistry.
Item Type: | Article |
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Source: | Copyright of this article belongs to Elsevier Science. |
ID Code: | 120769 |
Deposited On: | 05 Jul 2021 06:02 |
Last Modified: | 05 Jul 2021 06:02 |
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