Direct amino acid-catalyzed cascade reductive alkylation of arylacetonitriles: high-yielding synthesis of ibuprofen analogs

Ramachary, Dhevalapally B. ; Shiva Prasad, M. (2010) Direct amino acid-catalyzed cascade reductive alkylation of arylacetonitriles: high-yielding synthesis of ibuprofen analogs Tetrahedron Letters, 51 (40). pp. 5246-5251. ISSN 0040-4039

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Official URL: http://doi.org/10.1016/j.tetlet.2010.07.131

Related URL: http://dx.doi.org/10.1016/j.tetlet.2010.07.131

Abstract

A novel approach for a one-pot, three-component reductive alkylation (TCRA) reaction of arylacetonitriles-containing electron-withdrawing groups with aldehydes/ketones and 1,4-dihydropyridine via iminium-catalysis has been developed. Many TCRA reaction products have direct applications in agricultural and pharmaceutical chemistry.

Item Type:Article
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ID Code:120769
Deposited On:05 Jul 2021 06:02
Last Modified:05 Jul 2021 06:02

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