An Organocatalytic Azide-Aldehyde [3+2] Cycloaddition: High-Yielding Regioselective Synthesis of 1,4-Disubstituted 1,2,3-Triazoles

Ramachary, Dhevalapally B. ; Shashank, Adluri B. ; Karthik, S. (2014) An Organocatalytic Azide-Aldehyde [3+2] Cycloaddition: High-Yielding Regioselective Synthesis of 1,4-Disubstituted 1,2,3-Triazoles Angewandte Chemie International Edition, 53 (39). pp. 10420-10424. ISSN 1433-7851

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Official URL: http://doi.org/10.1002/anie.201406721

Related URL: http://dx.doi.org/10.1002/anie.201406721

Abstract

An organocatalytic azide–aldehyde [3+2] cycloaddition (organo-click) reaction of a variety of enolizable aldehydes is reported. The organo-click reaction is characterized by a high rate and regioselectivity, mild reaction conditions, easily available substrates with simple operation, and excellent yields with a broad spectrum of substrates. It constitutes an alternative to the previously known CuAAC, RuAAC, and IrAAC click reactions.

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ID Code:120670
Deposited On:03 Jul 2021 07:40
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