One-Pot Knoevenagel and [4 + 2] Cycloaddition as a Platform for Calliviminones

Roy, Pritam ; Anjum, S. Rehana ; Ramachary, Dhevalapally B. (2020) One-Pot Knoevenagel and [4 + 2] Cycloaddition as a Platform for Calliviminones Organic Letters, 22 (8). pp. 2897-2901. ISSN 1523-7060

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Official URL: http://doi.org/10.1021/acs.orglett.0c00518

Related URL: http://dx.doi.org/10.1021/acs.orglett.0c00518

Abstract

Bioactive compounds featuring an unusual core of spiro[5.5]undecenes and calliviminones were synthesized in very good yield with good regio- and diastereoselectivities through a one-pot Knoevenagel and [4 + 2] cycloaddition from the readily available aldehydes, cyclic-1,3-diones, dienes, and a catalytic amount of (s)-proline.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:120628
Deposited On:02 Jul 2021 08:28
Last Modified:02 Jul 2021 08:28

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