Glucose-Triggered Drug Delivery from Borate Mediated Layer-by-Layer Self-Assembly

Manna, Uttam ; Patil, Satish (2010) Glucose-Triggered Drug Delivery from Borate Mediated Layer-by-Layer Self-Assembly ACS Applied Materials & Interfaces, 2 (5). pp. 1521-1527. ISSN 1944-8244

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Official URL: http://doi.org/10.1021/am100139j

Related URL: http://dx.doi.org/10.1021/am100139j

Abstract

In this study, we report a novel approach for glucose-triggered anticancer drug delivery from the self-assembly of neutral poly(vinyl alcohol) (PVA) and chitosan. In the present study, we have fabricated multilayer thin film of PVA-borate and chitosan on colloidal particle (MF particle) and monitored the layer-by-layer growth using Zeta potential measurements. Formation of multilayer membrane on MF particle has been further characterized with transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM). Subsequently, disintegration of multilayer thin film and microcapsules was observed in presence of glucose. We investigated the disassembly of PVA-borate and chitosan self-assembly under CLSM and atomic force microscopy. These results suggest that this multilayer thin film is very efficient for encapsulation and release of DOX molecules above certain concentration of glucose (25 mM). This glucose-sensitive self-assembly is relevant for the application of anticancer therapeutic drug delivery.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:120595
Deposited On:02 Jul 2021 05:54
Last Modified:02 Jul 2021 05:54

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