Layer-by-Layer Assembled Thin Film of Albumin Nanoparticles for Delivery of Doxorubicin

Mohanta, Vaishakhi ; Madras, Giridhar ; Patil, Satish (2012) Layer-by-Layer Assembled Thin Film of Albumin Nanoparticles for Delivery of Doxorubicin Journal of Physical Chemistry C, 116 (9). pp. 5333-5341. ISSN 1932-7447

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Official URL: http://doi.org/10.1021/jp209479n

Related URL: http://dx.doi.org/10.1021/jp209479n

Abstract

Protein nanoparticles (NPs) have found significant applications in drug delivery due to their inherent biocompatibility, which is attributed to their natural origin. In this study, bovine serum abumin (BSA) nanoparticles were introduced in multilayer thin film via layer-by-layer self-assembly for localized delivery of the anticancer drug Doxorubicin (Dox). BSA nanoparticles (∼100 nm) show a high negative zeta potential in aqueous medium (−55 mV) and form a stable dispersion in water without agglomeration for a long period. Hence, BSA NPs can be assembled on a substrate via layer-by-layer approach using a positively charged polyelectrolyte (chitosan in acidic medium). The protein nature of these BSA nanoparticles ensures the biocompatibility of the film, whereas the availability of functional groups on this protein allows one to tune the property of the self-assembly to have a pH-dependent drug release profile. The growth of multilayer thin film was monitored by UV–visible spectroscopy, and the films were further characterized by atomic force microscopy (AFM) and field emission scanning electron microscopy (FESEM). The drug release kinetics of these BSA nanoparticles and their self-assembled thin film has been compared at a physiological pH of 7.4 and an acidic pH of 6.4.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:120554
Deposited On:01 Jul 2021 12:29
Last Modified:01 Jul 2021 12:29

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