Molecular cartography of leaf development — role of transcription factors

Abstract

Organ elaboration in plants occurs almost exclusively by an increase in cell number and size. Leaves, the planar lateral appendages of plants, are no exception. Forward and reverse genetic approaches have identified several genes whose role in leaf morphogenesis has been inferred from their primary effect on cell number and size, thereby distinguishing them as either promoters or inhibitors of cell proliferation and expansion. While such classification is useful in studying size control, a similar link between genes and shape generation is poorly understood. Computational modelling can provide a conceptual framework to re-evaluate the known genetic information and assign specific morphogenetic roles to the transcription factor-encoding genes. Here we discuss recent advances in our understanding of the roles of transcription factors in the planar growth of leaf lamina in two orthogonal dimensions.