Chanda, Tanmoy ; Chowdhury, Sushobhan ; Anand, Namrata ; Koley, Suvajit ; Gupta, Ashutosh ; Singh, Maya Shankar (2015) Synthesis of 3-hydroxyindanones via potassium salt of amino acid catalyzed regioselective intramolecular aldolization of ortho-diacylbenzenes Tetrahedron Letters, 56 (8). pp. 981-985. ISSN 0040-4039
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Official URL: http://doi.org/10.1016/j.tetlet.2015.01.077
Related URL: http://dx.doi.org/10.1016/j.tetlet.2015.01.077
Abstract
First organocatalytic intramolecular aldolization of ortho-diacylbenzenes to construct highly functionalized 3-hydroxyindanones is described. In this transformation a high trans-selectivity is achieved by the use of metal salt of amino acid. This method allows an easy access to the strained spirocyclic 3-hydroxyindanones related to a number of natural product frameworks. Synthesis of a new class of indole skeleton substituted by 3-hydroxyindanones added an extra essence to this new protocol.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Amino Acid Metal; Salt Ortho-Diacyl Benzene; Intramolecular-Aldol 3-Hydroxyindanone; Spiroindane. |
| ID Code: | 120249 |
| Deposited On: | 24 Jun 2021 10:57 |
| Last Modified: | 24 Jun 2021 10:57 |
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