Feil, R ; Khosla, Sanjeev (1999) Genomic imprinting in mammals: an interplay between chromatin and DNA methylation? Trends in Genetics, 15 (11). pp. 431-435. ISSN 0168-9525
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Official URL: http://doi.org/10.1016/S0168-9525(99)01822-3
Related URL: http://dx.doi.org/10.1016/S0168-9525(99)01822-3
Abstract
Most imprinted loci have key regulatory elements that are methylated on only one of the parental chromosomes. For several of these ‘differentially methylated regions’, recent studies establish that the unmethylated chromosome has a specialized chromatin organization that is characterized by nuclease hypersensitivity. The novel data raise the question of whether specific proteins and associated chromatin features regulate the allele-specificity of DNA methylation at these imprinting control elements.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | DNA Methylation; Imprinting; Chromatin Organization; H19; SNRPN. |
| ID Code: | 120047 |
| Deposited On: | 22 Jun 2021 05:25 |
| Last Modified: | 22 Jun 2021 05:25 |
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