Rossi, Ana M ; Sureshan, Kana M ; Riley, Andrew M ; Potter, Barry VL ; Taylor, Colin W (2010) Selective determinants of inositol 1,4,5-trisphosphate and adenophostin A interactions with type 1 inositol 1,4,5-trisphosphate receptors British Journal of Pharmacology, 161 (5). pp. 1070-1085. ISSN 0007-1188
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Official URL: http://doi.org/10.1111/j.1476-5381.2010.00947.x
Related URL: http://dx.doi.org/10.1111/j.1476-5381.2010.00947.x
Abstract
Adenophostin A (AdA) is a potent agonist of inositol 1,4,5-trisphosphate receptors (IP(3) R). AdA shares with IP(3) the essential features of all IP(3) R agonists, namely structures equivalent to the 4,5-bisphosphate and 6-hydroxyl of IP(3) , but the basis of its increased affinity is unclear. Hitherto, the 2'-phosphate of AdA has been thought to provide a supra-optimal mimic of the 1-phosphate of IP(3)
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to British Pharmacological Society. |
| ID Code: | 119871 |
| Deposited On: | 18 Jun 2021 05:04 |
| Last Modified: | 18 Jun 2021 05:04 |
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