Multicomponent one-pot solvent-free synthesis of functionalized unsymmetrical dihydro-1H-indeno[1,2-b]pyridines

Samai, Subhasis ; Chandra Nandi, Ganesh ; Kumar, Ram ; Singh, M.S. (2009) Multicomponent one-pot solvent-free synthesis of functionalized unsymmetrical dihydro-1H-indeno[1,2-b]pyridines Tetrahedron Letters, 50 (50). pp. 7096-7098. ISSN 0040-4039

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Official URL: http://doi.org/10.1016/j.tetlet.2009.10.022

Related URL: http://dx.doi.org/10.1016/j.tetlet.2009.10.022

Abstract

A simple and efficient synthesis of 4-aryl-4,5-dihydro-1H-indeno[1,2-b]pyridine derivatives has been achieved via a four-component cyclocondensation of 1,3-indanedione, aromatic aldehydes, β-ketoesters and ammonium acetate in one-pot in the absence of catalyst and solvent at room temperature on grinding. The present approach offers several advantages such as shorter reaction times, higher yields, low cost, simple work-up and easy purification.

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