One-pot straightforward approach to 2,3-disubstituted benzo/naphtho[b]furans via domino annulation of α-oxoketene dithioacetals and 1,4-benzo/naphthoquinone mediated by AlCl3 at room temperature

Verma, Girijesh Kumar ; Verma, Rajiv Kumar ; Shukla, Gaurav ; Anugula, Nagaraju ; Srivastava, Abhijeet ; Singh, Maya Shankar (2013) One-pot straightforward approach to 2,3-disubstituted benzo/naphtho[b]furans via domino annulation of α-oxoketene dithioacetals and 1,4-benzo/naphthoquinone mediated by AlCl3 at room temperature Tetrahedron, 69 (32). pp. 6612-6619. ISSN 0040-4020

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Official URL: http://doi.org/10.1016/j.tet.2013.05.128

Related URL: http://dx.doi.org/10.1016/j.tet.2013.05.128

Abstract

A versatile and convenient one-pot direct approach to 2,3-disubstituted benzo/naphtho[b]furans via domino annulation of α-oxoketene dithioacetals and 1,4-benzo/naphthoquinone has been achieved in the presence of aluminium chloride at room temperature. This protocol represents an extremely simple, straightforward and rapid entry to highly substituted benzo/naphtho[b]furans in good yields from easily viable starting materials under mild reaction conditions.

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