Verma, Girijesh Kumar ; Shukla, Gaurav ; Nagaraju, Anugula ; Srivastava, Abhijeet ; Singh, Maya Shankar (2014) In(OTf)3-mediated dehydrative annulation of β-ketothioamides with phenylglyoxal: one-pot access to diversely functionalized pyrrol-2-thiones Tetrahedron Letters, 55 (37). pp. 5182-5185. ISSN 0040-4039
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Official URL: http://doi.org/10.1016/j.tetlet.2014.07.062
Related URL: http://dx.doi.org/10.1016/j.tetlet.2014.07.062
Abstract
Indium triflate mediated first synthesis of diversely functionalized pyrrol-2-thiones has been developed by dehydrative annulation of beta-ketothioamides with phenylglyoxal through the domino Knoevenagel condensation/cyclization cascade in one-pot. This new simple strategy not only utilizes readily accessible starting material, but also allows the construction of 5-membered azaheterocycle with one quaternary carbon center as a result of the formation of two new (C-C and C-N) bonds in a single operation.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 119628 |
| Deposited On: | 15 Jun 2021 08:06 |
| Last Modified: | 15 Jun 2021 08:06 |
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